I've had to temporarily disable the Mollom plugin because it was causing an issue with image verification when there was no way to actually verify the image. I'm trying to determine if it's a comment plugin conflict or something else. However, Akismet works just fine and has with all the plugins I use.

@sun - I use the following plugins to enhance my comment form. Basic Comment Quicktags, Filosofo Comments Preview, Simple Comment Editing, Subscribe To Comments, and one small snippet of custom code to provide the ability to reply to comments while automatically linking the replies together.