The HostGator QuickInstall script does a good job and more secure than Fantastico (I have seen Fantastico leave wp-config.php permissions at 777 before).

I had a chance to talk with the team that developed the script at WordCamp Houston, great bunch of guys. One thing to note is that QuickInstall includes WP-Super Cache pre activated which works well with HostGator's servers as well as a plugin that puts a HostGator link in your footer.