I've got a decent sized site that was started with with Fantastico WP Install.. Currently the site supports a news type theme with 17 homepage loops, BuddyPress and Forums, it's been active for 2 years and I've never had a problem updating it or with any theme or plugin..I've tried

I have another site under construction, so far it's been under construction for about 6 months- That one is Buddy Press on top of multi-site - It has a really complex primary theme- that contains 8 mini themes inside - I've had no problem setting up network sites or anything else.. An update comes along, click the button, wait a second to be sure, then get on with life. That was started with a Softaolous one click install, that included the multi site install.. Subfolders only

I've also looked too closely at 1 and 1's one click install, and their support..

My father used to tell me if I couldn't find something nice about someone, to keep my mouth shut.. Good advice